Haematologica
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Haematologica, Vol 92, Issue 2, 264-266 doi:10.3324/haematol.10356
Copyright © 2007 by Ferrata Storti Foundation
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Acute Lymphoblastic Leukemia

Interleukin 7 requirement for survival of T-cell acute lymphoblastic leukemia and human thymocytes on bone marrow stroma

Maria T. Scupoli*,°,, Omar Perbellini*, Mauro Krampera*, Fabrizio Vinante*, Federica Cioffi*, Giovanni Pizzolo*

* Department of Clinical and Experimental Medicine, Section of Hematology
° Interdepartmental Laboratory for Medical Research (LURM), University of Verona, Italy

Correspondence: Maria Teresa Scupoli, PhD, Laboratorio Universitario di Ricerca Medica (LURM), Università di Verona, Policlinico GB Rossi, Ple. L.Scuro, 10 37134 Verona, Italy. Phone: international +39.045.8074261. Fax: international +39.045.8027403. E-mail: mariateresa.scupoli{at}univr.it

We explored the role of interleukin-7 (IL-7) in the bone marrow (BM) stroma-mediated survival of primary T-cell acute lymphoblastic leukemia (T-ALL) cells and normal thymocytes. We present evidence that IL-7 has a major role in the enhanced survival mediated by BM stroma both in T-ALL cells and thymocytes.

Key words: T-ALL, thymocytes, BM stroma, IL-7, survival, proliferation.




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M. T. Scupoli, M. Donadelli, F. Cioffi, M. Rossi, O. Perbellini, G. Malpeli, S. Corbioli, F. Vinante, M. Krampera, M. Palmieri, et al.
Bone marrow stromal cells and the upregulation of interleukin-8 production in human T-cell acute lymphoblastic leukemia through the CXCL12/CXCR4 axis and the NF-{kappa}B and JNK/AP-1 pathways
Haematologica, April 1, 2008; 93(4): 524 - 532.
[Abstract] [Full Text] [PDF]


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Copyright © 2007 by the Ferrata Storti Foundation.