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MUM1 expression dichotomizes follicular lymphoma into predominantly, MUM1-negative low-grade and MUM1-positive high-grade subtypes

Department of Histopathology, Hammersmith Hospital & Imperial College, London, UK

Correspondence: Kikkeri N Naresh, Haematopathologist, Department of Histopathology, Hammersmith Hospital & Imperial College, Du Cane Road, W12 0HS, London UK. Phone: international +44.20.83833969. Fax: international +44.20.83838140. E-mail: k.naresh{at}imperial.ac.uk

We investigated the expression of MUM1 (multiple myeloma oncogene 1)/IRF4 (interferon regulatory factor 4) in 46 cases of follicular lymphoma (FL) and correlated this with grade and expression of CD10, Bcl-6 and Ki-67. The analysis suggests that MUM1 expression dichotomizes FL into low-grade FL of CD10⁺/Bcl-6⁺/MUM1^–/Ki-67^low pheno-type, and high-grade FL of CD10^+/–/Bcl-6^+/weak/MUM1⁺/Ki-67^high phenotype.

Key words: follicular lymphoma, MUM1, IRF4, Bcl-6, Bcl-2, CD10, Ki-67, germinal center, B-cell.