Haematologica
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Haematologica, Vol 92, Issue 2, 271-272 doi:10.3324/haematol.10737
Copyright © 2007 by Ferrata Storti Foundation
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Malignant Lymphomas

Gemcitabine, cisplatin and methylprednisolone for the treatment of patients with peripheral T-cell lymphoma: the Royal Marsden Hospital experience

Hendrik-Tobias Arkenau*, Geoff Chong*, David Cunningham*,, David Watkins*, Bhawna Sirohi*, Ian Chau*, Andrew Wotherspoon°, Andy Norman#, Alan Horwich@, Estella Matutes^

* Department of Medicine, Royal Marsden Hospital, London and Sutton
° Department of Histopathology, Royal Marsden Hospital, London
# Department of Computing, Royal Marsden Hospital, Sutton
@ Department of Clinical Oncology, Royal Marsden Hospital, Sutton
^ Department of Hematology, Royal Marsden Hospital, Sutton, UK

Correspondence: David Cunningham, Department of Medicine, Royal Marsden Hospital, Downs Road, M2 5PT Sutton, Surrey, United Kingdom. Phone: international +44.0207.3528171, Fax: international +44.0208.6939414, E-mail: david.cunningham{at}rmh.nhs.uk

Novel, effective therapies are needed for peripheral T-cell non-Hodgkin’s lymphoma (PTCL). We treated 16 patients with a combination of gemcitabine, cisplatin and methylprednisolone (GEM-P). Three patients (19%) achieved a complete remission and eight (50%) a partial remission. GEM-P has encouraging efficacy with an acceptable toxicity profile in patients with PTCL.

Key words: T-cell lymphoma, PTCL, gemcitabine, cisplatin, methylprednisolone, GEM-P.




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[Abstract] [Full Text] [PDF]


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Copyright © 2007 by the Ferrata Storti Foundation.