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Monitoring serum free light chains in patients with multiple myeloma who achieved negative immunofixation after allogeneic stem cell transplantation

Bone Marrow Transplantation, University Hospital Hamburg-Eppendorf, Hamburg, Germany

Correspondence: Nicolaus Kröger, Bone Marrow Transplantation, University Hospital Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany. Phone: international +49.40.42803/5864. Fax: international +49.40.42803/3795. E-mail: nkroeger{at}uke.uni-hamburg.de

Monitoring of serum free immunoglobulin light chains (FLC) in 26 myeloma patients who achieved immunofixation negativity after allografting showed a decrease of FLC at a median of 128 days before immunofixation negativity. In patients who subsequently relapsed, a 25% increase of FLC was observed at a median of 98 days before immunofixation positivity.

Key words: multiple myeloma, free light chain assay, immunofixation.