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Prothrombotic coagulation abnormalities in patients with newly diagnosed multiple myeloma

^* Department of Haematology, Erasmus University Medical Center, Rotterdam
^° Department of Internal Medicine Ikazia Hospital, Rotterdam, the Netherlands

Correspondence: Johannes J.A. Auwerda, MD, Erasmus MC, Dept of Hematology, 3000 CA Rotterdam, PO Box 2040, the Netherlands. Phone: international +31.10.4633740. Fax: internatioal +31.10.4635814. E-mail: jja.auwerda{at}ikazia.nl

Prothrombotic coagulation abnormalities were analyzed in patients with untreated multiple myeloma. Increases in factor VIII, in von Willebrand factor and a decrease in protein S were observed and these changes were strongly associated with disease stage. No difference in baseline coagulation parameters was found between patients with and without subsequent venous thromboembolism.

Key words: newly diagnosed multiple myeloma, coagulation abnormalities, vWF, factor VIII, antiphospholipid antibodies, protein S.

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