Haematologica
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Haematologica, Vol 92, Issue 2, 287-288 doi:10.3324/haematol.10647
Copyright © 2007 by Ferrata Storti Foundation
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Thrombosis

Elevated factor XIII level and the risk of myocardial infarction in women

Zsuzsanna Bereczky*, Emilia Balogh°, Éva Katona*, István Czuriga°, István Édes°, László Muszbek*,

* Clinical Research Center, Thrombosis and Haemostasis Research Group of the Hungarian Academy of Sciences
° Department of Cardiology, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary

Correspondence: László Muszbek MD, PhD, Clinical Research Center, Medical and Health Science Center, University of Debrecen, P.O. Box 40, 4012 Debrecen, Hungary. Fax: international +3652340011. E-mail: muszbek{at}med.unideb.hu

Factor XIII (FXIII) activity and antigen levels were determined in 955 patients investigated by coronary angiography. Patients were sub-grouped according to the presence or absence of coronary sclerosis (CS+, CS–) and a positive history of myocardial infarction (MI+, MI–). In females, but not in males, adjusted FXIII activity and antigen levels were significantly elevated in the CS+MI+ group compared to in the CS+MI– group. FXIII levels in the upper tertile were associated with significantly increased risk of MI in females, but not in males.

Key words: factor XIII, coronary sclerosis, myocardial infarction, women.




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