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Haematologica, Vol 92, Issue 3, 405-409 doi:10.3324/haematol.10268
Copyright © 2007 by Ferrata Storti Foundation
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Malignant Lymphomas

The translocations t(6;18;11)(q24;q21;q21) and t(11;14;18)(q21;q32;q21) lead to a fusion of the API2 and MALT1 genes and occur in MALT lymphomas

Eva M. Murga Penas, Evelyne Callet-Bauchu, Hongtao Ye, Kristina Hinz, Nadine Albert, Christiane Copie-Bergman, Sophie Gazzo, Françoise Berger, Gilles Salles, Carsten Bokemeyer, Ming-Qing Du, Judith Dierlamm

From the University Medical Center Hamburg-Eppendorf, Hamburg, Germany (EMMP, KH, NA, CB, JD); Centre Hospitalier Lyon Sud, Lyon, France (EC-B, SG, FB, GS); University of Cambridge, Cambridge, United Kingdom (HY, M-QD); Hospital Henri Mondor, Créteil, France CC-B).

Correspondence: Judith Dierlamm, M.D., Ph.D., Department of Oncology and Hematology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany. E-mail: judith_dierlamm{at}yahoo.de

So far, only one variant translocation of the t(11;18)(q21;q21), the t(11;12;18) (q21;q13;q21), has been reported. We herein describe two new variant translocations, the t(6;18;11)(q24;q21;q21) and the t(11;14;18)(q21;q32;q21), occurring in mucosa-associated lymphoid tissue (MALT) lymphomas. In both cases, fluorescence in situ hybridization (FISH) and reverse transcriptase polymerase chain reaction (RT-PCR) revealed the presence of an 5'API2-3'MALT1 fusion product, encoded on the derivative chromosome 11. Exon 7 of API2 was fused with exon 5 of MALT1 in the t(11;14;18) and with exon 8 of MALT1 in the t(6;18;11). FISH revealed the involvement of the immunoglobulin locus in the t(11;14;18). Rapid amplification of cDNA ends (RACE)-PCR to detect the involved partner gene on 6q showed exclusively wild-type API2 and MALT1 sequences.

Key words: t(11, 18), MALT1, variant translocation, MALT lymphoma.






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