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Haematologica, Vol 92, Issue 3, 429-430 doi:10.3324/haematol.10632
Copyright © 2007 by Ferrata Storti Foundation
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Chronic Myeloid Leukemia

Monitoring BCR-ABL transcript levels by real-time quantitative polymerase chain reaction: a linear regression equation to convert from BCR-ABL/B2M ratio to estimated BCR-ABL/ABL ratio

Ilaria Iacobucci, Livia Galletti, Marilina Amabile, Simona Soverini, Michele Baccarani, Giovanni Martinelli

From Department of Hematology/Oncology "L. and A. Seràgnoli" S. Orsola Malpighi Hospital, University of Bologna, Bologna, Italy

Correspondence: Giovanni Martinelli, Molecular Biology Unit, Department of Hematology/Oncology "L. and A. Seràgnoli" S. Orsola Malpighi Hospital, University of Bologna, Via Massarenti, 9, 40138 Bologna, Italy. Phone: international +0039.051.6363829. Fax: international + 0039.051.6364037. E-mail: gmartino{at}kaiser.alma.unibo.it

In order to overcome the problem of different control genes for BCR-ABL normalization, we used a linear regression equation to compare our results previously obtained using B2M as the control gene with those calculated using the ABL gene and validated the slope as a factor to convert from B2M to ABL results.

Key words: BCR-ABL ratio, RT-PCR.




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