Haematologica, Vol 92, Issue 4, 542-545 doi:10.3324/haematol.10758
Copyright © 2007 by Ferrata Storti Foundation
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Acute Myeloid Leukemia

Effect of histone deacetylase inhibitor valproic acid on progenitor cells of acute myeloid leukemia

Gesine Bug, Kerstin Schwarz, Claudia Schoch, Manuela Kampfmann, Reinhard Henschler, Dieter Hoelzer, Oliver G. Ottmann, Martin Ruthardt

From the Medizinische Klinik II, Abt. Hämatologie/Onkologie, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Frankfurt, Germany (GB, KS, MK, DH, OGO, MR); MLL Münchner Leukämielabor GmbH, München, Germany (CS); Institut für Transfusionsmedizin und Immunhämatologie, DRK-Blutspendedienst Baden-Württemberg - Hessen GmbH, Frankfurt, Germany (RH).

Correspondence: Gesine Bug, Medizinische Klinik II, Abt. Hämatologie/Onkologie, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany. Email: g.bug{at}em.uni-frankfurt.de

Histone deacetylase inhibitor valproic acid (VPA) was recently shown to enhance proliferation and self-renewal of normal hematopoietic stem cells, raising the possibility that VPA may also support growth of leukemic progenitor cells (LPC). Here, VPA maintains a significantly higher proportion of CD34+ LPC and colony forming units compared to control cultures in six AML samples, but selectively reduces leukemic cell numbers in another AML sample with expression of AML1/ETO. Our data suggest a differential effect of VPA on the small population of AML progenitor cells and the bulk of aberrantly differentiated blasts in the majority of AML samples tested.

Key words: histone deacetylase inhibitor, CD34+ leukemic progenitor cells, interphase FISH, AML1/ETO, AML blast colonies.




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