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Doxorubicin pharmacokinetics in lymphoma patients treated with doxorubicin-loaded eythrocytes

National Research Center for Hematology, Russian Academy of Medical Sciences, Moscow, Russia

Correspondence: Oleksii A. Skorokhod, Department of Genetics, Biology, and Biochemistry, University of Torino Medical School, Via Santena 5 bis, 10126 Torino, Italy. Phone: international +39.011.7905850. Fax: international +39.011.7905845. E-mail: olexii.skorokhod{at}unito.it

Doxorubicin-loaded erythrocytes (DLE) were administrated to 15 lymphoma patients. Antibiotic peak concentration in blood decreased by 55%, doxorubicin circulated several times longer, and the area under the concentration-time curve increased 5 times if compared with standard doxorubicin administration. The DLE was well tolerated by patients.

Key words: doxorubicin, carrier erythrocytes, pharmacokinetics, lymphoma.