Haematologica, Vol 92, Issue 4, 574-575 doi:10.3324/haematol.10891
Copyright © 2007 by Ferrata Storti Foundation
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Lymphoproliferative Disorders

Increased MDM2 expression is associated with inferior survival in mantle cell lymphoma, but not related to the MDM2 SNP309

Elena Hartmann*, Verònica Fernàndez°, Heike Stoecklein*, Luis Hernández°, Elías Campo°, Andreas Rosenwald*,

* Institute of Pathology, University of Würzburg, Germany
° Hematopathology Section, Department of Pathology, Hospital Clinic, University of Barcelona, Spain

Correspondence: Andreas Rosenwald, M.D., Institute of Pathology, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany.

We here show that increased expression of MDM2, a negative regulator of p53, correlates with inferior survival in a series of 43 mantle cell lymphomas. MDM2 overexpression is associated with copy number gains of the MDM2 locus in single tumors, but not with the recently reported MDM2 promoter SNP309.

Key words: mantle cell lymphoma, MDM2 expression, survival, SNP309.




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