Haematologica, Vol 92, Issue 4, e56-e58 doi:10.3324/haematol.11394
Copyright © 2007 by Ferrata Storti Foundation
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Online Only Articles

First case of successful allogeneic stem cell transplantation in an HIV-patient who acquired severe Aplastic Anemia

T. Wolf1,, V. Rickerts1, S. Staszewski2, S. Kriener4, B. Wassmann3, G. Bug3, M. Bickel, P. Gute6, H.R. Brodt1, H. Martin

1 From the: Department of Infectious Diseases
2 HIV Center
3 Department of Hematology/Oncoloy
4 Department of Pathology, Hospital of the Johann Wolfgang Goethe University, Frankfurt, Germany
6 HIV specialist practice Friedensstraße, Frankfurt, Germany

Corresponding author and requests for reprints: Dr. Timo Wolf, Department of Infectious Diseases, Hospital of the JW Goethe University, Frankfurt, Germany, Timo.wolf{at}kgu.de, Tel.: +49 69 6301 5452 Fax: +49 69 6301 6378

We report on the first successful allogeneic stem cell transplantation (SCT) in an HIV-infected patient with severe aplastic anemia (SAA) performed at a tertiary care institution. Highly active antiretroviral therapy (HAART) was administered until transplantation and restarted 34 days later with sustained virological response. The patient did however develop a rapid rise in HIV load during the interruption of HAART associated with an acute febrile illness. Due to the extended period between the onset of SAA until SCT, the posttransplant course was complicated by bacterial infections. Stage two skin GvHD, but no AIDS-defining opportunistic diseases were experienced. Neutrophils recovered to >0.5/nL on day +18 and the CD4 count reached 250/µL on day +71 and >500/µL on day +182. The patient is in good condition with an ECOG score of 0 twelve months after transplantation. This report demonstrates the feasibility of allogeneic stem cell transplantation in the HIV setting.

Key words: Haematology, HIV, Bone marrow transplantation, Severe aplastic anemia.