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Expression of ß^E and -globin genes in infants heterozygous for hemoglobin E and double heterozygous for hemoglobin E and -thalassemia

^* Thalassemia Research Center, Institute of Science and Technology for Research and Development
^° Institute of Nutrition, Mahidol University, Salaya, Nakornpathom, Thailand

Correspondence: Pranee Winichagoon, Ph.D., Thalassemia Research Center, Institute of Science and Technology for Research and Development, Mahidol University, 25/25 Phuttamonthon 4 Rd., Salaya, Phuttamonthon, Nakornpathom 73170, Thailand. Phone: international +66.2.8892558. Fax: international +66-2-8892559. E-mail: stpfc{at}mahidol.ac.th

This study described the expression of ß^E-globin in newborns heterozygous for HbE. Despite the lower level of HbE, the pattern of ß^E-globin gene expression was similar to ß^A-globin because the increase in HbE and HbA reached the peak level at the same time. A delayed decline of HbF was observed.

Key words: thalassemia, hemoglobin E, hemoglobin F, neonatal screening, globin gene expression.