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Accuracy of leukocyte alkaline phosphatase score to predict JAK2 V617F mutation

^* Department of Hematology and Oncology, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina
^° Centro Piloto para Detección de Errores Metabólicos (CEPIDEM), Universidad Nacional de Córdoba, Córdoba, Argentina

Correspondence: Ana Lisa Basquiera, MD, Department of Hematology and Oncology, Hospital Privado Centro Médico de Córdoba, Naciones Unidas 346 (5016), Córdoba, Argentina. Phone: international +54.351.4688250. Fax: international +54.351.4688270. E-mail: anabasquiera{at}arnet.com.ar

Granulocyte activation parameters have been described in patients with myeloproliferative disorders (MPD). We have evaluated the accuracy of leukocyte alkaline phosphatase (LAP) score to predict JAK2 V617F mutation. LAP score was obtained using a cytochemical reaction in granulocytes of patients’ peripheral blood with MPD.

Key words: LAP, JAK2, myeloproliferative disorders, sensitivity, specificity.