Haematologica
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Haematologica, Vol 92, Issue 5, 706-707 doi:10.3324/haematol.10923
Copyright © 2007 by Ferrata Storti Foundation
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Malignant Lymphomas

ALK-mediated Na+/H+ exchanger-dependent intracellular alkalinization: does it matter for oncogenesis?

Francesco Turturro*,, Michael Driscoll*, Ellen Friday*, Tomas Welbourne°

* Feist-Weiller Cancer Center Department of Medicine
° Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA

Correspondence: Francesco Turturro, LSUHSC, 1501 Kings Highway, Shreveport, LA 71103, USA. Phone: international +1.318.6758863. Fax: international +1.318.6754338. E-mail: fturtu{at}lsuhsc.edu

In this study we investigated the relevance of the oncogenic protein NPM-ALK in regulating cellular pH (pHi) through the modulation of Na+/H+ exchanger 1 (NHE1)-activity and the consequences of pHi pharmacological manipulation in cells expressing NPM-ALK.

Key words: ALK, ALCL, NHE1, Troglitazone.






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