HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Pellegrini, W. Articles by Facchetti, F. Search for Related Content PubMed PubMed Citation Articles by Pellegrini, W. Articles by Facchetti, F.

MMA monoclonal antibody is a superior anti-CD15 reagent for the diagnosis of classical Hodgkin’s lymphoma

Department of Pathology, Spedali Civili, University of Brescia, Brescia, Italy

Correspondence: Fabio Facchetti, Department of Pathology, Spedali Civili Brescia, 25124 Brescia, Italy. E-mail: facchett{at}med.unibs.it

CD15 is a useful immunohistochemical marker to identify Reed-Sternberg cells in classical Hodgkin’s lymphoma (HL) and to distinguish it from HD-like neoplasms, but data from the literature concerning its expression in HL are quite variable. Using immunohistochemistry we compared the reactivity of three different anti-CD15 clones (MMA, C3D1 and BY87) and found that anti-CD15 MMA clone is a superior reagent in identifying atypical cells, detecting more numerous cells in 28.2%, and being the only positive marker in 12.8% of cases. We conclude that it is advisable to include this reagent in diagnostic immunohistochemical panels.

Key words: CD15, classical Hodgkin lymphoma, immunohistochemistry.