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Hypercoagulability resulting from opposite effects of lupus anticoagulants is associated strongly with thrombotic risk

Thomas Lecompte^*,°, Denis Wahl^*,#,, Christine Perret-Guillaume^@, H. Coenraad Hemker^{^}, Patrick Lacolley, Véronique Regnault^*

^* Inserm, U734; 1UHP, Nancy University;
^° Haematology Laboratory, Nancy University, Nancy, France
^# Vascular Medicine and
^@ Internal Medicine, Nancy University Hospital, Nancy, France:
^{^} Synapse B.V., CARIM, University of Maastricht, The Netherlands
Inserm, U684; 1UHP

Correspondence: Denis Wahl, Inserm U734, UHP, Faculté de Médecine, 54500 Vandoeuvre-lès-Nancy, France. Phone: international +33.3.83683476. Fax: international +33.3.83683479. E-mail: d.wahl{at}chu-nancy.fr

Interference of antiphospholipid antibodies (aPL) with coagulation was investigated in 40 aPL-patients (24 with thrombosis) using thrombography. Impairment of the activated protein C anticoagulant pathway was partially offset by the genuine anticoagulant effect. The net result, a procoagulant phenotype, was associated with a 7-fold increased risk of thrombosis in aPL-patients.

Key words: antiphospholipid antibody, antiphospholipid syndrome, lupus anticoagulant, APC resistance, thrombin generation.

This article has been cited by other articles:

				A. Membre, D. Wahl, V. Latger-Cannard, J.-P. Max, P. Lacolley, T. Lecompte, and V. Regnault The effect of platelet activation on the hypercoagulability induced by murine monoclonal antiphospholipid antibodies Haematologica, April 1, 2008; 93(4): 566 - 573. [Abstract] [Full Text] [PDF]