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Quantification by magnetic resonance imaging and liver consequences of post-transfusional iron overload alone in long-term survivors after allogeneic hematopoietic stem cell transplantation

From the Department of Hematology, Catholic University of Lille, Hospital St. Vincent de Paul, Lille, France; Department of Radiology, CHU Lille, France; Department of clinical research, Téreo, Loos, France; Laboratory of Biochemistry, CHU, Lille, France; Department of Hematology, CHU, Lille, France

Correspondence: Professor Christian Rose, Service d’Hématologie, Groupe Hospitalier de l’Institut Catholique, Université Catholique de Lille, (GHICL), Hôpital Saint Vincent Boulevard de Belfort, 59020 Lille, France. E-mail: Rose.Christian{at}ghicl.net

We quantified and studied the impact of post transfusional iron overload alone in post allogeneic HSCT. Median number of RBCs was 18. Ferritin was 532 µg/L. Liver iron content (LIC) was 117 µmoles/gdw. Correlation RBCs and ferritin was (r=0.81); RBCs and LIC was (r=0.84). The high ferritin group differed from normal ferritin group in terms of RBCs transfused (p<10^–3), ALT (p<0.009). But occurrence of liver dysfunction was not significant. Magnitude of iron overload correlates closely to the number of RBCs and is quantified by MRI. Impact on liver dysfunction is moderate in absence of co-morbidity.

Key words: manetic resonance imaging, iron overlaod, allogeneic hematopoietic stem cell transplantation.