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A simple method for detection of major phenotypic abnormalities in myelodysplastic syndromes: expression of CD56 in CMML

^* Laboratoire d’Hématologie,
^° Service d’Hématologie Clinique
^# Service de Chirurgie Cardio-Vasculaire
^@ UMR CNRS 6101, CHU Dupuytren et Faculté de Médecine, Université de Limoges, France

Correspondence: Jean Feuillard, Laboratoire d'Hématologie et UMR CNRS 6101, CHU Dupuytren, 2 Avenue Martin Luther King, 87042 Limoges Cedex, France. Phone: international +33.0555.056740. Fax: international +33.0555.056185. E-mail: jean.feuillard{at}chu-limoges.fr

Using a very simple flow cytometry protocol, we found that CD36 and CD117 on granulocytes and CD56 on monocytes were the major bone marrow phenotypic aberrations in patients with myelodysplasia, including CMML. CD56 on monocytes was associated with CMML. Importantly, phenotypic aberrations were lost on blood cells, except for CD56.