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AML1 mutation and its coexistence with different transcription factor gene families in de novo acute myeloid leukemia: redundancy or synergism

^* Department of Medicine,
^° Department of Immunology; Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
^# Chulabhorn Cancer Centre, Chulabhorn Research Institute, Bangkok, Thailand
^@ Office of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

Correspondence: Chirayu U. Auewarakul, MD, PhD, Division of Hematology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Rd, Bangkoknoi, Bangkok 10700, Thailand. Phone: international +662.4197000/4449: Fax: international +662.4181602. E-mail: chirayuaue{at}yahoo.com

AML1 mutations were identified in 6.3% of AML patients with chromosomal translocations involving CBF, PML-RAR, HOX, or ETS transcription factor (TF) gene families. Rare chromosomal abnormalities, t(16;21) and t(7;11), were also found. This study represents the first series to demonstrate the coexistence of known and novel AML1 mutations with different TF gene mutations. Although the occurrence of two TF gene mutations may appear unnecessary, the possible synergistic mechanism between different TF gene families cannot be excluded and needs to be further explored.

Key words: acute myeloid leukemia, transcription factor, AML1 mutation, leukemogenesis, cooperative events.

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