Haematologica
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Haematologica, Vol 92, Issue 6, 863-864 doi:10.3324/haematol.10656
Copyright © 2007 by Ferrata Storti Foundation
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Malignant Lymphomas

Deregulated over expression of FOXP1 protein in diffuse large B-cell lymphoma does not occur as a result of gene rearrangement

Sharon L. Barrans, James A.L. Fenton*, Roland Ventura°, Alex Smith#, Alison H. Banham°, Andrew S. Jack*

* HMDS, Academic Unit of Haematology and Oncology, Leeds General Infirmary, Leeds, LS1 3EX, United Kingdom
° University of Oxford, Nuffield Department of Clinical Laboratory Sciences, LRF Lymphoma Antigens Programme, John Radcliffe Hospital, Oxford, UK;
# Epidemiology and Genetics Unit, University of York, York, UK

Correspondence: Sharon L Barrans, HMDS, Academic Unit of Haematology and Oncology, Leeds General Infirmary, Leeds, LS1 3EX, United Kingdom. Phone: international + 44.11.33926285. Fax: international +44.11.33926286. E-mail: sharonb{at}hmds.org.uk

Strong uniform expression of FOXP1 protein occurs in a subgroup of non-germinal centre (GC) diffuse large B-cell lymphomas (DLBCL). We have investigated gene rearrangement as a potential mechanism for deregulated expression of FOXP1 however, using FISH FOXP1 translocations were not found in any case with over-expression of the protein.




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P. J. Brown, S. L. Ashe, E. Leich, C. Burek, S. Barrans, J. A. Fenton, A. S. Jack, K. Pulford, A. Rosenwald, and A. H. Banham
Potentially oncogenic B-cell activation-induced smaller isoforms of FOXP1 are highly expressed in the activated B cell-like subtype of DLBCL
Blood, March 1, 2008; 111(5): 2816 - 2824.
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