Haematologica, Vol 92, Issue 7, 921-927 doi:10.3324/haematol.10191
Copyright © 2007 by Ferrata Storti Foundation
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Malignant Lymphomas

The pattern of genomic gains in salivary gland MALT lymphomas

Yuanping Zhou, Hongtao Ye, Jose I. Martin-Subero, Stefan Gesk, Rifat Hamoudi, Yong-Jie Lu, Rubin Wang, Janet Shipley, Reiner Siebert, Peter G. Isaacson, Ahmet Dogan, Ming-Qing Du

Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom (YZ, HY, RH, M-QD); Nanfang Hospital, Southern Medical University, Guangzhou, China (YZ); Institute of Human Genetics, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany (JIM-S, SG, RS); Molecular Cytogenetics, Institute of Cancer Research, Sutton, United Kingdom (Y-JL, RW, JS); Department of Histopathology, University College London, London, UK (PGI, AD)

Correspondence: Ming-Qing Du, Professor of Oncological Pathology, Division of Molecular Histopathology, Department of Pathology University of Cambridge, Box 231, Level 3 Lab Block, Addenbrooke’s Hospital Hills Road, Cambridge, CB2 2QQ United Kingdom. E-mail: mqd20{at}cam.ac.uk

Background and Objectives: Salivary gland mucosa-associated lymphoid tissue (MALT) lymphomas typically lack chromosomal translocations and the molecular genetics underlying their development is unknown. The aim of this study was to investigate chromosomal changes in these lymphomas.

Design and Methods: We performed comparative genomic hybridisation using DNA samples extracted from microdissected tumour cells in 19 salivary gland MALT lymphomas. Recurrent chromosomal changes were further verified by interphase fluorescence in situ hybridization (FISH).

Results: Chromosomal gains were much more common than losses. Recurrent gains were found at 1p32-ter (42%), 9q33–34 (84%), 11q11–13 (42%), 17 (58%) and 18q21–22 (42%). Among these, the recurrent gains at 9q34, 11q11–13 and 18q21 were nearly the exclusive gain of the corresponding chromosome. Notably, chromosomal gains at 9q34, 11q13 and 18q21 were frequently concurrent, with 12/19 cases affecting at least two of the three loci. The genomic gains at these chromosomal regions were further confirmed by interphase FISH with probes targeting the TRAF2 and CARD9 (9q34), RELA and CCND1 (11q13), and MALT1 (18q21) loci.

Interpretation and Conclusions: Salivary gland MALT lymphomas show a conserved pattern of chromosomal gains, which appear to target genes positively modulating cell survival and proliferation.

Key words: salivary gland, MALT lymphoma, CGH.




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