Haematologica, Vol 92, Issue 7, 992-993 doi:10.3324/haematol.10658
Copyright © 2007 by Ferrata Storti Foundation
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Red Cell Disorders

Elucidating the spectrum of {alpha}-thalassemia mutations in Iran

Valeh Hadavi*, Amir Hossein Taromchi*,, Mahdi Malekpour*, Behjat Gholami*, Hai-Yang Law°, Navid Almadani*, Fariba Afroozan*, Farhad Sahebjam*, Parisa Pajouh*, Roxana Kariminejad*, Mohammad Hassan Kariminejad*, Azita Azarkeivan*,#, Maryam Jafroodi*, Ahmad Tamaddoni@, Helene Puehringer^, Christian Oberkanins^, Hossein Najmabadi*

* Kariminejad-Najmabadi Pathology & Genetics Center, Tehran, Iran
° DNA Diagnostic & Research Lab, KK Women’s and Children Hospital, Singapore
# Iranian Blood Transfusion Organization (IBTO), Research Center, Iran;
@ Amirkola Thalassemia Center, Babol University of Medical Science, Babol, Iran
^ ViennaLab Diagnostics GmbH, Vienna, Austria

Correspondence: Hossein Najmabadi, Professor of Genetics, Kariminejad-Najmabadi Pathology & Genetics Center, 14665/154, Tehran, Iran. Phone: international +98.21.88363952. E-mail: hnajm{at}mavara.com

{alpha} thalassemia ({alpha}-thal) is one of the most common hemoglobin (Hb) disorders in the world.1 {alpha}-globin genes are located on chromosome 16. The majority of {alpha}-thal mutations are deletions but point mutations are found as well.2 Since the Iranian population is a mixture of different ethnic groups, frequency and distribution of {alpha}-globin mutations in various regions of the country need to be clarified. These findings can contribute to a wider understanding of this disorder.

Key words: {alpha} thalassemia, mutation, Iran.