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Asthma is associated with Increased mortality in individuals with sickle cell anemia

From the Department of Pediatrics, Division of Allergy and Pulmonary Medicine,Washington University School of Medicine, St. Louis, MO, USA (JHB, RCS); New England Research Institutes,Watertown, MA, USA (EAM); Department of Pediatrics, Division of Genetics, Washington University School of Medicine, St. Louis, MO, USA (MRDB)

Correspondence: Michael R. DeBaun MD, MPH, Washington University School of Medicine in St. Louis, 4444 Forest Park Blvd, CB 8519, St Louis, MO 63108 USA. E-mail: debaun_m{at}kids.wustl.edu

An analysis of a prospective cohort of individuals with sickle cell anemia (SCA), enrolled from birth through adulthood, was conducted to determine if asthma is a risk factor for death in SCA. All-cause mortality was determined for participants after adjusting for known risk factors for death in SCA. The study included 1,963 individuals who were followed for 18,495 patient-years. After controlling for established risk factors, individuals with SCA and asthma had a more than two-fold higher risk of mortality (hazard ratio 2.36, 95% CI 1.21 to 4.62, p=0.01). To summarize, asthma is a risk factor for death in SCA.

Key words: sickle cell anemia, mortality, asthma.