Red Cell Disorders |
From the Department of Pediatrics, Division of Allergy and Pulmonary Medicine,Washington University School of Medicine, St. Louis, MO, USA (JHB, RCS); New England Research Institutes,Watertown, MA, USA (EAM); Department of Pediatrics, Division of Genetics, Washington University School of Medicine, St. Louis, MO, USA (MRDB)
Correspondence: Michael R. DeBaun MD, MPH, Washington University School of Medicine in St. Louis, 4444 Forest Park Blvd, CB 8519, St Louis, MO 63108 USA. E-mail: debaun_m{at}kids.wustl.edu
An analysis of a prospective cohort of individuals with sickle cell anemia (SCA), enrolled from birth through adulthood, was conducted to determine if asthma is a risk factor for death in SCA. All-cause mortality was determined for participants after adjusting for known risk factors for death in SCA. The study included 1,963 individuals who were followed for 18,495 patient-years. After controlling for established risk factors, individuals with SCA and asthma had a more than two-fold higher risk of mortality (hazard ratio 2.36, 95% CI 1.21 to 4.62, p=0.01). To summarize, asthma is a risk factor for death in SCA.
Key words: sickle cell anemia, mortality, asthma.
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