Haematologica, Vol 92, Issue 8, 1135-1138 doi:10.3324/haematol.11133
Copyright © 2007 by Ferrata Storti Foundation
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Multiple Myeloma

Demonstration of changes in plasma cell subsets in multiple myeloma

Michael John Ayliffe, Faith Elizabeth Davies, David de Castro, Gareth John Morgan

From the Department of Immunology, St. Helier Hospital, Carshalton, Surrey, UK (MJA); Section of Haemato-Oncology, The Royal Marsden NHS Foundation Trust, UK (FED, DdC, GJM)

Correspondence: Michael J. Ayliffe, Department of Immunology, St Helier Hospital Wrythe Lane, Carshalton, Surrey, SM3 8NR, UK. E-mail: michael.ayliffe{at}onetel.net

Increases in free light chain (FLC) production are associated with disease progression in multiple myeloma (MM). Using a double immunofluorescence staining method to produce a differential count of plasma cells in bone marrow, single populations were demonstrated, containing intact monoclonal immunoglobulins (M-Igs) in 74% and FLCs only in 8% of cases. However, 18% contained a mixture of both cell populations. Progression from cells making intact M-Ig to cells restricted to FLC only production occurred in individual cases during the course of their disease. The presence of FLC only cells was associated with shortened survival.

Key words: multiple myeloma, bone marrow, plasma cells, free light chains, monoclonal immunoglobulins.




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