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Vitamin D receptor gene polymorphisms and risk of non-Hodgkin’s lymphoma

^* Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD
^° The University of Sydney, Sydney, AUS
^# National Centre for HIV Epidemiology and Clinical Research, Sydney, Australia

Correspondence: Mark Purdue, PhD, Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8121, MSC 7240, Rockville, MD, 20892-7240, USA. Phone: international +001.301.4515036. Fax: international +001.301.4021819. E-mail purduem{at}mail.nih.gov

We studied three vitamin D receptor gene (VDR) polymorphisms (BsmI, TaqI, FokI) in a case-control study of non-Hodgkin’s lymphoma. The BsmI B and TaqI t alleles were associated with an increased risk of diffuse large B-cell lymphoma. These findings suggest that variants in VDR may influence lymphomagenesis.

Key words: vitamin D receptor, case-control study, non-Hodgkin’s lymphoma, polymorphisms, Australia.