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Lactadherin mediates sickle cell adhesion to vascular endothelial cells in flowing blood

Department of Medicine (Thrombosis Research) (PG, SY JAL, PT) and Pathology Baylor College of Medicine (SKD, AL, PT) and Michael E. DeBakey Veterans Affairs Medical Center Houston, Tx, USA (PT)

Correspondence: Perumal Thiagarajan, MD, Michael E. DeBakey VA Medical Center, Mail stop #113, 2002 Holcombe Blvd, Houston, TX 77030, USA. Phone: international +1.713.7947873. Fax: international +1.713.7947657. E-mail.perumalt{at}bcm.tmc.edu

Increased exposure of sickle red blood cells to phosphatidylserine promotes its adhesion to the endothelium. A monoclonal antibody to lactadherin, a phosphatidylserine binding protein, inhibits sickle cell adhesion to histamine-stimulated endothelial cells in flowing blood. Added lactadherin enhances the adhesion via the integrin Vß3. These results indicate that lactadherin can mediate phosphatidyl-serine-expressing sickle cell adhesion to the endothelium.

Key words: lactadherin, sickle cell anemia, phosphatidyl-serine, endothelial adhesion.