Haematologica, Vol 92, Issue 9, 1273-1274 doi:10.3324/haematol.11329
Copyright © 2007 by Ferrata Storti Foundation
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Acute Myeloid Leukemia

Sustained molecular remission after low dose gemtuzumab-ozogamicin in elderly patients with advanced acute promyelocytic leukemia

Massimo Breccia, Giuseppe Cimino, Daniela Diverio, Fabiana Gentilini, Franco Mandelli, Francesco Lo Coco

Department of Cellular Biotechnology and Hematology, University La Sapienza, Rome, Italy (MB, GC, DD, FG,FM); Department of Biopathology, University of Tor Vergata, Rome, Italy (FL-C)

Correspondence: Massimo Breccia, MD, Dept. of Human Biotechnology and Hematology, Via Benevento 6, 00161 Rome, Italy. Phone: international +39.06.857951. Fax: international +39.06.44241984. E-mail: breccia{at}bce.uniroma1.it

We report here a preliminary experience with gemtuzumab ozogamicin (GO) used at low dosage (3 mg/m2) in 3 elderly patients with acute promyelocytic leukaemia (APL) who presented molecular relapse and were unfit for intensive chemotherapy.

Key words: acute promyelocytic leukemia, gentuzumab ozogamicin, molecular relapse.




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