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Identification of a novel e8/a4 BCR/ABL fusion transcript in a case of a transformed Sézary syndrome

^* Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud
^° Université Claude Bernard, UMR 5239, Pierre-Bénite, France
^# Service d’Hématologie Biologique; Service d’Hématologie Clinique
^@ Service de Dermatologie (Hotel-Dieu)
^{^} Service d'Anatomie Pathologique, Pierre-Bénite, France

Correspondence: Evelyne Callet-Bauchu, Laboratoire d’Hématologie et de Cytogénétique, Centre Hospitalier Lyon sud, 6 9495 Pierre Bénite, France. Phone: international +33.478861515. Fax: international +33.478864104. E-mail: sandrine.hayette{at}chu-lyon.fr/ evelyne.callet-bauchu{at}chu-lyon.fr

This report deals with a case of Sézary syndrome, a rare peripheral T-cell lymphoproliferative disorder, in which cytogenetic analysis performed during the disease transformation revealed the presence of a t(9;22) (q34;q11.2) translocation. Molecular analyses identified a new transcript, an e8a4 BCR-ABL fusion mRNA which could be responsible for the disease transformation.