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Expression of functional toll-like receptors by B-chronic lymphocytic leukemia cells

^* Laboratoire d’Immunologie, EA3441-IFR 111, Faculté de Médecine Nancy Université and CHU de Nancy, 9 Avenue de la Forêt de Haye, BP 184, 54500 Vandoeuvre les Nancy, France
^° Service d’Hématologie Adulte, CHU de Nancy, Allée du Morvan, 54500 Vandoeuvre les Nancy, France

Correspondence: Pierre Feugier, Hématologie Adulte, Hôpitaux de Brabois, Allée du Morvan, 54 500 Vandoeuvre les Nancy, France. Phone: international +33.383153282. Fax: international +33.383153558. E-mail: p.feugier{at}chunancy.fr

This study reports that B-chronic lymphocytic leukemia (B-CLL) cells display the same pattern of toll-like receptors (TLRs) proteins expression as normal B-cells, yet with overexpression of TLR9. Furthermore, TLR7 and TLR9 appear to be functional and liable to respond to specific ligands, respectively imidazoquinolines and CpG-ODN thus potentially opening new therapeutic approaches.

Key words: TLR, B-CLL, imiquimod, ODN.