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Role of ozone therapy in the treatment of osteonecrosis of the jaws in multiple myeloma patients

^* Hematology, Department of Cellular Biotechnologies and Hematology
^° Clinica Maxillo-Facial University "La Sapienza" of Rome, Italy

Correspondence: Maria Teresa Petrucci, MD, Hematology, Department of Cellular Biotechnologies and Hematology, University "La Sapienza", Via Benevento 6, 00161 Rome, Italy. Phone: international +39.06.857951. Fax: international +39.06.441639810. E-mail: petrucci{at}bce.uniroma1.it

Current treatments for bisphosphonate-associated osteonecrosis of the jaw (ONJ) in multiple myeloma patients have limited efficacy. The biological effects of ozone indicate it may be therapeutic for ONJ. We, here, report the efficacy of a 15-day course of antibiotics, surgery and ozone therapy in 12 MM patients with ONJ.

Key words: ozone therapy, osteonecrosis of the jaw, multiple myeloma, bisphosphonates.