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Vascular endothelial growth factor promoted endothelial progenitor cell mobilization into the peripheral blood of a patient with POEMS syndrome

Vittorio Rosti^*,, Margherita Massa^°, Rita Campanelli^#, Mara De Amici^@, Giovanni Piccolo, Vittorio Perfetti^{^}

^* Laboratory of Organ Transplantation;
^° Laboratory of Biotechnology;
^# Laboratory of Clinical Epidemiology;
^@ Departments of Pediatrics;
^{^} Institute of Internal Medicine I, Fondazione IRCCS Policlinico San Matteo;
IRCCS Istituto Neurologico C. Mondino, Pavia, Italy

Correspondence: Vittorio Rosti, MD, Laboratory of Organ Transplantation, Fondazione IRCCS Policlinico San Matteo, Piazzale Golgi 19, 27100 Pavia, Italy. Phone: international +39. 0382.502162. Fax: international +39.0382.526223. E-mail: virosti{at}tin.it

We assessed the percentage of endothelial progenitor cells (EPCs) in the peripheral blood of a patient with POEMS with elevated VEGF plasma levels. High VEGF plasma levels were associated with increased EPC concentration and treatment with an anti-VEGF antibody induced a consensual decrease of both parameters. In vitro cultures of the patient BM cells suggested that the stromal compartment could be responsible for VEGF overproduction.