HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Rosti, V. Articles by Perfetti, V. Search for Related Content PubMed PubMed Citation Articles by Rosti, V. Articles by Perfetti, V.

Vascular endothelial growth factor promoted endothelial progenitor cell mobilization into the peripheral blood of a patient with POEMS syndrome

Vittorio Rosti^*,, Margherita Massa^°, Rita Campanelli^#, Mara De Amici^@, Giovanni Piccolo, Vittorio Perfetti^{^}

^* Laboratory of Organ Transplantation;
^° Laboratory of Biotechnology;
^# Laboratory of Clinical Epidemiology;
^@ Departments of Pediatrics;
^{^} Institute of Internal Medicine I, Fondazione IRCCS Policlinico San Matteo;
IRCCS Istituto Neurologico C. Mondino, Pavia, Italy

Correspondence: Vittorio Rosti, MD, Laboratory of Organ Transplantation, Fondazione IRCCS Policlinico San Matteo, Piazzale Golgi 19, 27100 Pavia, Italy. Phone: international +39. 0382.502162. Fax: international +39.0382.526223. E-mail: virosti{at}tin.it

We assessed the percentage of endothelial progenitor cells (EPCs) in the peripheral blood of a patient with POEMS with elevated VEGF plasma levels. High VEGF plasma levels were associated with increased EPC concentration and treatment with an anti-VEGF antibody induced a consensual decrease of both parameters. In vitro cultures of the patient BM cells suggested that the stromal compartment could be responsible for VEGF overproduction.