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Metabolic syndrome and hyperhomocysteinemia in patients with deep vein thrombosis: a case-control study

^* Department of Clinical Medicine, University of Insubria, Varese, Italy
^° Department of Medical and Surgical Sciences, 2^nd Chair of Internal Medicine, University of Padua, Italy
^# Department of Internal Medicine, Angiology Unit, Reggio Emilia Hospital, Reggio Emilia, Italy

Correspondence: Walter Ageno, U.O. Medicina I, Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy. Phone: international +39.0332.278594. Fax: international +39.0332.278229. E-mail: agewal{at}yahoo.com

We evaluated the prevalence of the metabolic syndrome (MS) and of hyperhomocysteinemia in patients with unprovoked deep vein thrombosis (DVT) and in controls. The MS and hyperhomocysteinemia were significantly more prevalent in DVT patients than in controls. However, only the MS resulted independently associated with DVT, and the coexistence of both risk factors did not increase the magnitude of the association.

Key words: metabolic syndrome, hyperhomocysteinemia, deep vein thrombosis.