Haematologica, Vol 93, Issue 1, 116-119 doi:10.3324/haematol.11768
Copyright © 2008 by Ferrata Storti Foundation
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Red Cell Disorders

A T2* magnetic resonance imaging study of pancreatic iron overload in thalassemia major

Wing-Yan Au1,, Wynnie Wai-Man Lam3, Winnie Chu3, Sidney Tam4, Wai-Keng Wong4, Raymond Liang1, Shau-Yin Ha2

1Departments of Medicine and 2Pediatrics and Adolescent Medicine, The University of Hong Kong, Queen Mary Hospital (SYH); 3Department of Diagnostic Radiology, Chinese, University of Hong Kong, Prince of Wales; 4Clinical Biochemistry Unit, Queen Mary Hospital, Hong Kong, China

Correspondence: Win-Yan Au, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong. E-mail: auwing{at}hotmail.com

We studied the utility of pancreatic magnetic resonance imaging (MRI) in 72 thalassemia major patients (21 diabetic, 51 normoglycemic). Diabetic patients were significantly older (p<0.0001) and had smaller pancreas volume (p<0.0001). The two groups were comparable for ferritin and MRI-T2* heart, liver and pancreas. Pancreatic T2* signals were abnormal in 80% of both groups, and correlated with heart T2*. In normoglycemic patients, cardiac T2* and log-pancreatic T2* values correlated with homeostatic model assessments HOMA-B (β cell reserve), HOMA-IR (insulin resistance) and fasting insulin/C-peptide levels. This suggested that improved chelation may improve β cell reserve and prevent pancreatic atrophy.

Key words: magnetic resonance, thalassemia.




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