Haematologica
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Haematologica, Vol 93, Issue 1, 145-146 doi:10.3324/haematol.11927
Copyright © 2008 by Ferrata Storti Foundation
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Malignant Lymphomas

Chromosomal translocations involving BCL6 in MALT lymphoma

Hongtao Ye1, Ellen D. Remstein2, Chris M. Bacon1, Andrew G. Nicholson3, Ahmet Dogan2, Ming-Qing Du1,

1 Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
2 Divisions of Anatomic Pathology and Hematopathology, Mayo Clinic, Rochester, USA
3 Department of Histopathology, Royal Brompton Hospital, London, United Kingdom

Correspondence: Ming-Qing Du, Professor of Oncological Pathology, Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Box 231, Level 3, Lab block, Addenbrooke’s Hospital Hills Road, Cambridge CB2 0QQ, United Kingdom. Tel: +44.1223.767092. Fax: +44.1223. 586670. Email: mqd20{at}cam.ac.uk

Chromosomal translocations involving BCL6 were detected in 7 out of 392 cases of MALT lymphoma by interphase fluorescence in situ hybridisation with a BCL6 break-apart probe. With the exception of BCL6 protein expression in 2 of the 7 cases, these BCL6 translocation-positive MALT lymphomas were histologically and immunophenotypically identical to classic cases.




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