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High-dose chemotherapy and autologous stem-cell transplantation without consolidating radiotherapy as first-line treatment for primary lymphoma of the central nervous system

¹ Departments of Haematology and Oncology
² Neuropathology
³ Radiology
⁴ Stereotactic Neurosurgery, University Medical Center Freiburg, Freiburg, Germany

Correspondence: Gerald Illerhaus, MD, University Medical Center Freiburg, Dept. of Hematology and Oncology, Hugstetter Str. 55, D-79106 Freiburg, Germany., Phone: international +49.761.2703785. Fax: international +49.761.270.7357. E-mail: gerald.illerhaus{at}uniklinik-freiburg.de

Thirteen patients (age 38–67 years) with primary lymphoma of the central nervous system (CNS) were treated with methotrexate and cytarabine/thiotepa induction-chemotherapy followed by high-dose carmustine/thiotepa and autologous stem-cell transplantation. Radiotherapy was restricted to patients who did not respond completely to chemotherapy. With a median follow up of 25 months, 3-year DFS and OS was 77%.

Key words: PCNSL, high-dose chemotherapy, stem-cell transplantation, whole-brain-radiotherapy, neurotoxicity.