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Decrease in the frequency of meningeal involvement in AIDS-related systemic lymphoma in patients receiving HAART

¹ Department of Hematology, Institut Català d’Oncologia and
² Department of Pathology, Hospital Germans Trias i Pujol, Badalona, Universitat Autònoma de Barcelona, Spain

Correspondence: José-Tomás Navarro, Department of Hematology, Institut Català d’Oncologia, Hospital Germans Trias i Pujol, Badalona, Ctra. De Canyet s/n, 08916, Badalona, Barcelona, Spain. Phone: international +34.9.34978868. E-mail: jtnavarr{at}ico.scs.es

We evaluated the frequency of primary central nervous system lymphoma and leptomeningeal involvement in systemic non-Hodgkin’s lymphoma (NHL) in HIV-infected patients. Those receiving highly active antiretroviral therapy (HAART) showed a decrease in leptomeningeal involvement in systemic NHL (0/30 vs. 12/87; p=0.023). Therefore HAART could prevent CNS involvement in systemic NHL.

Key words: frequency, meningeal, AIDS, lymphoma.