4th Palermo Conference on INNOVATIVE THERAPIES FOR LYMPHOID MALIGNANCIES
Haematologica, Vol 93, Issue 1, 155-156 doi:10.3324/haematol.12050
Copyright © 2008 by Ferrata Storti Foundation
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kirito, K.
Right arrow Articles by Komatsu, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kirito, K.
Right arrow Articles by Komatsu, N.

Platelet Disorders

A novel RUNX1 mutation in familial platelet disorder with propensity to develop myeloid malignancies

Keita Kirito1, Kumi Sakoe1, Daisuke Shinoda1, Yoshihisa Takiyama2, Kenneth Kaushansky3, Norio Komatsu1,

1 Department of Hematology, University of Yamanashi, Chuo-shi, Yamanashi
2 Division of Neurology, Department of Internal Medicine, Jichi Medical University, Shimotuke, Tochigi, Japan.
3 Department of Medicine, Division of Hematology/Oncology University of California, San Diego, CA, USA

Correspondence: Norio Komatsu M.D., Ph.D., Department of Hematology, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, Japan 409-3898. Phone: international +81.55.2739432. Fax: international +81.55.2731274. E-mail: komatsun{at}yamanashi.ac.jp

We describe a Japanese family with familial platelet disorder with propensity to develop myeloid malignancies (FPD/MM). Among the three affected individuals, two members developed myeloid malignancies. Sequence studies demonstrate that all affected individuals of the pedigree display a heterozygous single nucleotide deletion in exon 8 of the RUNX1 gene.

Key words: RUNX1, acute myeloid leukemia, FPD/MM.




This article has been cited by other articles:


Home page
 BloodHome page
J.-L. Tang, H.-A. Hou, C.-Y. Chen, C.-Y. Liu, W.-C. Chou, M.-H. Tseng, C.-F. Huang, F.-Y. Lee, M.-C. Liu, M. Yao, et al.
AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations
Blood, December 17, 2009; 114(26): 5352 - 5361.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. Preudhomme, A. Renneville, V. Bourdon, N. Philippe, C. Roche-Lestienne, N. Boissel, N. Dhedin, J.-M. Andre, P. Cornillet-Lefebvre, A. Baruchel, et al.
High frequency of RUNX1 biallelic alteration in acute myeloid leukemia secondary to familial platelet disorder
Blood, May 28, 2009; 113(22): 5583 - 5587.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. J. Owen, C. L. Toze, A. Koochin, D. L. Forrest, C. A. Smith, J. M. Stevens, S. C. Jackson, M.-C. Poon, G. D. Sinclair, B. Leber, et al.
Five new pedigrees with inherited RUNX1 mutations causing familial platelet disorder with propensity to myeloid malignancy
Blood, December 1, 2008; 112(12): 4639 - 4645.
[Abstract] [Full Text] [PDF]