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Human herpesvirus-6 DNAemia in immunosuppressed adult patients with leukemia at risk for mold infection

Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M.D. Anderson Cancer Center, Houston, Tx, USA

Correspondence: Roy F. Chemaly, MD, MPH, Department of Infectious Diseases, Infection Control, and Employee Health, Unit 402, The University of Texas M.D. Anderson Cancer Center, P.O. Box 301402, Houston, TX 77230-1402, USA. Phone: international +713.7451116. Fax: international +713.7456839. E-mail: rfchemaly{at}mdanderson.org

Little is known about human herpesvirus-6 (HHV-6) in leukemia patients. We prospectively followed 37 leukemia patients at risk for mold infection. HHV-6 DNA was detected from whole blood specimens in 11 patients (30%). History of granulocyte transfusions (p=0.05) and prior relapse of leukemia (p=0.07) were the only independent predictors of HHV-6 DNAemia.

Key words: human herpesvirus-6, DNAemia, polymerase chain reaction, leukemia, granulocytes transfusion.