Haematologica, Vol 93, Issue 1, 157-158 doi:10.3324/haematol.11638
Copyright © 2008 by Ferrata Storti Foundation
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Infectious Disorders

Human herpesvirus-6 DNAemia in immunosuppressed adult patients with leukemia at risk for mold infection

Roy F. Chemaly, Harrys A. Torres, Ray Hachem, Dimitrios P Kontoyiannis, Amar Safdar, Issam I. Raad

Department of Infectious Diseases, Infection Control, and Employee Health, The University of Texas M.D. Anderson Cancer Center, Houston, Tx, USA

Correspondence: Roy F. Chemaly, MD, MPH, Department of Infectious Diseases, Infection Control, and Employee Health, Unit 402, The University of Texas M.D. Anderson Cancer Center, P.O. Box 301402, Houston, TX 77230-1402, USA. Phone: international +713.7451116. Fax: international +713.7456839. E-mail: rfchemaly{at}mdanderson.org

Little is known about human herpesvirus-6 (HHV-6) in leukemia patients. We prospectively followed 37 leukemia patients at risk for mold infection. HHV-6 DNA was detected from whole blood specimens in 11 patients (30%). History of granulocyte transfusions (p=0.05) and prior relapse of leukemia (p=0.07) were the only independent predictors of HHV-6 DNAemia.

Key words: human herpesvirus-6, DNAemia, polymerase chain reaction, leukemia, granulocytes transfusion.