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Improving outcomes of acute invasive Aspergillus rhinosinusitis n patients with hematologici malignancies or aplastic anemia: the role of voriconazole

¹ Dipartimento di Biotecnologie Cellulari ed Ematologia, Università "La Sapienza", Rome
² Pfizer Italia, Rome, Italy

Correspondence: Corrado Girmenia, MD, Dipartimento di Biotecnologie Cellulari ed Ematologia, University "La Sapienza" of Rome, via Benevento 6, 00161 Rome Italy. Phone: international +39.06.857951. Fax: international +39.06.44241984. E-mail: girmenia{at}bce.uniroma1.it

We evaluated the outcomes of patients with hematologic diseases diagnosed with acute invasive Aspergillus rhinosinusitis comparing a group of patients diagnosed after voriconazole was available at our center with a historical group of patients diagnosed before voriconazole was available. Voriconazole use was associated with a decrease in mortality and earlier clinical response.

Key words: rhinosinusitis, aspergillus, hematologic malignancies, voriconazole.