Haematologica
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Haematologica, Vol 93, Issue 1, e21-e23 doi:10.3324/haematol.12085
Copyright © 2008 by Ferrata Storti Foundation
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Online Only Articles

Human Herpes virus 8-negative primary effusion lymphoma with BCL6 rearrangement in a patient with idiopathic CD4 positive T-lymphocytopenia

D. Niino1,, K. Tsukasaki3, K. Torii3, D. Imanishi3, T. Tsuchiya5, Y. Onimaru5, H. Tsushima3, S. Yoshida2, Y. Yamada4, S. Kamihira4, M. Tomonaga3

1 Department of Pathology
2 Department of Internal Medicine, National National Hospital Organization Nagasaki Medical Center, Omura
3 Department of Hematology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki
4 Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki
5 Department of Hematology, Sasebo Municipal General Hospital, Sasebo, Japan

Correspondence: Daisuke Niino, M.D., Ph.D., Department of Pathology, National Nagasaki Medical Center, 2-1001-1, Kubara, Omura, Nagasaki 856-8562, Japan. Phone: +81.957.523121. Fax: +81.957.540292. E-mail: niino522{at}yahoo.co.jp

Primary effusion lymphoma (PEL) was initially designated as a body-cavity-based lymphoma and recognized as a distinct clinical entity without a contiguous tumor mass. PEL was first reported in patients with acquired immunodeficiency syndrome (AIDS) and the distinctive feature of PEL originally reported as a B-cell neoplasm characterized by infection of the tumor cells by human herpes virus 8 (HHV-8).1 However, there have recently been several reports of PEL in patients without human immunodeficiency virus (HIV) or HHV8 infection.2–4

Key words: primary effusion lymphoma, Idiopathic CD4 positive T-lymphocytopenia, BCL6 rearrangement, Epstein-Barr virus, chemotherapy.






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