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Serum hepcidin level and erythropoietic activity after hematopoietic stem cell transplantation

¹ Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto
² Proteomics Research Unit, Division of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Ishikawa
³ Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya
⁴ Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan

Correspondence: Hiroshi Kawabata, Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto 606-8507, Japan. E-mail:hkawabat{at}kuhp.kyoto-u.ac.jp

The relationship between serum hepcidin, a key regulator of body iron homeostasis, and erythropoiesis was investigated before and after stem cell transplantation in 31 patients with hematopoietic malignancies. Serum hepcidin-25 was monitored using a liquid chromatography-tandem mass spectrometry-based assay system. Other iron- and erythropoiesis-related parameters and known hepcidin regulators, such as interleukin-6 and growth differentiation factor-15, were also monitored. The serum hepcidin level peaked one week after stem cell transplantation, followed by a gradual decrease with a parallel change in interleukin-6 and a reciprocal change in reticulocyte count. Multivariate regression analysis demonstrated that the serum hepcidin level at four weeks after stem cell transplantation showed significant inverse correlations with erythropoietic activity markers, such as the soluble transferrin receptor, but not with growth differentiation factor-15. These results indicate the existence of an unknown functional erythropoiesis-associated circulating factor, other than growth differentiation factor-15, that negatively regulates hepcidin production in stem cell transplantation settings.

Key words: hepcidin, iron metabolism, stem cell transplantation, erythropoiesis.

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				C. Camaschella and L. Silvestri New and old players in the hepcidin pathway Haematologica, October 1, 2008; 93(10): 1441 - 1444. [Full Text] [PDF]