Haematologica
HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS
QUICK SEARCH:   [advanced]


     

Published online 26 January 2008
Haematologica, Vol 93, Issue 2, 193-200 doi:10.3324/haematol.11702
Copyright © 2008 by Ferrata Storti Foundation
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Tzankov et al. Supplementary data
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tzankov, A.
Right arrow Articles by Dirnhofer, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tzankov, A.
Right arrow Articles by Dirnhofer, S.
Related Collections
Right arrowRelated Articles

Malignant Lymphomas

Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin’s lymphoma

Alexandar Tzankov1,, Cecile Meier1, Petra Hirschmann1, Philip Went2, Stefano A. Pileri3, Stephan Dirnhofer1

1 Institute of Pathology, University Hospital Basel, Switzerland;
2 Institute of Pathology, Triemli Hospital, Zurich, Switzerland;
3 Chair of Pathology and Unit of Hematopathology, Institute of Hematology and Clinical Oncology "L. and A. Seràgnoli", University of Bologna, Italy

Correspondence: Alexandar Tzankov, MD, Department of Pathology, University Hospital Basel, Schoenbeinstr. 40, CH-4031 Basel, Switzerland. E-mail: atzankov{at}uhbs.ch

Background: The tumor microenvironment is important for the behavior of cancer. We assessed the distribution and biological significance of FOXP3+ regulatory T-cells (Treg) in lymphomas.

Design and Methods: The absolute number of intratumoral FOXP3+ cells was immunohistochemically studied on lymphoma tissue microarrays from 1019 cases of different types of lymphomas and correlated to phenotypic and clinical parameters in uni- and multivariate models. Receiver operating characteristic -curves were used to determine prognostic cut-off values of FOXP3+ cell density.

Results: Of the 1019 cases, 926 (91%) were evaluable. FOXP3+ cell density varied between the lymphoma entities, and was highest in follicular lymphoma. An increased number of tumor-infiltrating FOXP3+ cells over the receiver operating characteristic-determined cut-offs positively influenced both disease-specific and failure-free survival in follicular lymphoma (p=0.053) and disease-specific survival in germinal center-like diffuse large B-cell lymphoma (p=0.051) and overall and failure-free survival in classical Hodgkin’s lymphoma (p=0.004), but had a negative prognostic effect in non-germinal center diffuse large B-cell lymphoma (p=0.059). In a Cox regression model, considering stage and age, the amount of FOXP3+ cells was of independent prognostic significance for failure-free survival in classical Hodgkin’s lymphoma and of borderline significance for overall survival in classical Hodgkin’s lymphoma and disease-specific survival in germinal center-like and non-germinal center diffuse large B-cell lymphoma.

Conclusions: FOXP3+ cells represent important lymphoma/host microenvironment modulators. Assessment of FOXP3+ cell density can contribute to the prediction of outcome in diffuse large B-cell lymphoma, fallicular lymphoma and classical Hodgkin’s lymphoma.

Key words: lymphoma, Treg, FOXP3, tissue microarray, receiver operating characteristic curves.


Related Articles

High clinical and molecular response rates with fludarabine, cyclophosphamide and mitoxantrone in previously untreated patients with advanced stage follicular lymphoma
Silvia Montoto, Carol Moreno, Eva Domingo-Doménech, Cristina Estany, Albert Oriol, Albert Altés, Joan Besalduch, Carme Pedro, Santiago Gardella, Lourdes Escoda, Antoni Asensio, Pilar Vivancos, Pilar Galán, Alberto Fernández de Sevilla, Josep M. Ribera, Javier Briones, Dolors Colomer, Elías Campo, Emili Montserrat, Armando López-Guillermo for the Grup per l’Estudi dels Limfomes de Catalunya I Balears (GELCAB) Spain
Haematologica 2008 93: 207-214. [Abstract] [Full Text] [PDF]

Fludarabine-melphalan as a preparative regimen for reduced-intensity conditioning allogeneic stem cell transplantation in relapsed and refractory Hodgkin’s lymphoma: the updated M.D. Anderson Cancer Center experience
Paolo Anderlini, Rima Saliba, Sandra Acholonu, Sergio A. Giralt, Borje Andersson, Naoto T. Ueno, Chitra Hosing, Issa F. Khouri, Daniel Couriel, Marcos de Lima, Muzaffar H. Qazilbash, Barbara Pro, Jorge Romaguera, Luis Fayad, Frederick Hagemeister, Anas Younes, Mark F. Munsell, Richard E. Champlin
Haematologica 2008 93: 257-264. [Abstract] [Full Text] [PDF]



This article has been cited by other articles:


Home page
 BloodHome page
B. Chetaille, F. Bertucci, P. Finetti, B. Esterni, A. Stamatoullas, J. M. Picquenot, M. C. Copin, F. Morschhauser, O. Casasnovas, T. Petrella, et al.
Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome
Blood, March 19, 2009; 113(12): 2765 - 3775.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Mittal, N. A. Marshall, L. Duncan, D. J. Culligan, R. N. Barker, and M. A. Vickers
Local and systemic induction of CD4+CD25+ regulatory T-cell population by non-Hodgkin lymphoma
Blood, June 1, 2008; 111(11): 5359 - 5370.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS
Copyright © 2008 by the Ferrata Storti Foundation.