Haematologica
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Haematologica, Vol 93, Issue 2, 303-306 doi:10.3324/haematol.11960
Copyright © 2008 by Ferrata Storti Foundation
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Stem Cell Transplantation

Reduced intensity conditioning allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation

Mohamad Mohty1,, Myriam Labopin2, Reza Tabrizzi3, Niklas Theorin4, Axel A Fauser5, Alessandro Rambaldi6, Johan Maertens7, Shimon Slavin8, Ignazio Majolino9, Arnon Nagler10, Didier Blaise11, Vanderson Rocha2,12 on behalf of the Acute Leukemia Working Party

1 Service d’Hématologie Clinique, CHU Hôtel Dieu, Université de Nantes, Nantes, France;
2 European Group for Blood and Marrow Transplantation (EBMT), Acute Leukemia Working Party, Hopital Saint-Antoine, Assistance Publique des Hôpitaux de Paris and Université de Paris 6, Pierre et Marie Curie, Paris, France;
3 Centre Hospitalo-Universitaire de Bordeaux, Hôpital Haut-Leveque, Pessac, France;
4 University Hospital, Dept. of Hematology, Linköping, Sweden;
5 Klinik fuer Knochenmarktransplantation und Haematologie/Onkologie, Idar-Oberstein, Germany;
6 Ospedale Bergamo, Divisione di Ematologia, Bergamo, Italy;
7 University Hospital Gasthuisberg, Dept. of Hematology, Leuven, Belgium;
8 Hadassah University Hospital, Department of Bone Marrow Transplantation, Jerusalem, Israel;
9 Ospedale S. Camillo-Forlanini, Dept. of Hematology and BMT, Rome, Italy;
10 Tel-Aviv University, Chaim Sheba Medical Center, Tel-Hashomer, Israel;
11 Unité de Transplantation et de Thérapie Cellulaire, Institut Paoli-Calmettes, Marseille, France and
12 Department of Hematology, Hopital Saint-Louis, Assistance Publique Hopitaux de Paris, Paris, France

Correspondence: Mohamad Mohty, M.D., Ph.D., Service d’Hématologie Clinique, CHU Hôtel-Dieu, Université de Nantes, Place Alexis Ricordeau, F-44093 Nantes, France. E-mail: mohamad.mohty{at}univ-nantes.fr

This retrospective study reported the outcome of 97 adult acute lymphoblastic leukemia patients who received a reduced-intensity conditioning allogeneic stem cell transplantation. With a median follow-up of 2.8 years, two year overall-survival, leukemia-free survival and non-relapse mortality were significantly better in patients transplanted in first complete remission (CR1, 52±9%; 42±10%; and 18±7% respectively) compared with those transplanted in more advanced phase (p=0.003, p=0.002 and p=0.01 respectively). In multivariate analysis, disease status (CR1 vs. advanced; p=0.001) and chronic graft-vs-host disease (p=0.01) were associated with an improved overall-survival, suggesting that reduced-intensity conditioning allogeneic stem cell transplantation is feasible in patients with high risk lymphoblastic leukemia in remission at transplantation.

Key words: allogeneic SCT, acute lymphoblastic leukemia.






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