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Atrial dysfunction as a marker of iron cardiotoxicity in thalassemia major

Division of Cardiology, Children’s Hospital of Los Angeles, Los Angeles, CA, USA

Correspondence: John C. Wood, Division of Cardiology, Mailstop 34, Children’s Hospital of Los Angeles, Los Angeles, CA, 90027 USA. Phone: international + 1.323.6695470/3236697317. E-mail: jwood{at}chla.usc.edu

We measured left atrial size and function from biplane MRI data in 62 adults with thalassemia major. Age-adjusted left atrial ejection fraction was depressed in 7 out of 20 subjects having T2* < 10 ms. Left atrial size, left ventricular size and cardiac output fell with cardiac iron loading, representing increased cardiac or peripheral vascular stiffness.

Key words: Keywords: thalassemia, diastolic function, systolic function, iron overload, MRI.