Haematologica
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Haematologica, Vol 93, Issue 2, 319-321 doi:10.3324/haematol.11950
Copyright © 2008 by Ferrata Storti Foundation
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Malignant Lymphomas

Rare occurrence of IgVH gene translocations and restricted IgVH gene repertoire in ocular MALT-type lymphoma

Patrick Adam, Eugenia Haralambieva, Martina Hartmann, Zhengrong Mao, German Ott*, Andreas Rosenwald*

Institute of Pathology, University of Würzburg, Germany

Correspondence: Patrick Adam, MD, Institute of Pathology, University of Würzburg, Josef-Schneider-Str. 2 97080 Würzburg, Germany. Phone: international +49.931.20147877. Fax: international +49.931.20147505. E-mail: patrick.adam{at}mail.uni-wuerzburg.de

FISH studies on 37 ocular MALT-type lymphomas yielded chromosomal translocations affecting MAL andT1 BCL10 in 1 case each, no evidence for a break in the FOXP1 locus, and trisomy 3 in 14 out of 34 cases (41%). Three out of 8 cases analyzed used the highly mutated VH3-23 gene and showed ongoing somatic hypermutations.






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