Haematologica
HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS
QUICK SEARCH:   [advanced]


     

Published online 11 February 2008
Haematologica, Vol 93, Issue 3, 439-442 doi:10.3324/haematol.12153
Copyright © 2008 by Ferrata Storti Foundation
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (2)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Falini, B.
Right arrow Articles by Schnittger, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Falini, B.
Right arrow Articles by Schnittger, S.

Acute Myeloid Leukemia

NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: a comparative analysis of 2562 patients with acute myeloid leukemia

Brunangelo Falini1,, Cristina Mecucci1, Giuseppe Saglio2, Francesco Lo Coco3, Daniela Diverio4, Patrick Brown5, Fabrizio Pane6, Marco Mancini4, Maria Paola Martelli1, Stefano Pileri7, Torsten Haferlach8, Claudia Haferlach8, Susanne Schnittger8

1 Institute of Hematology, University of Perugia, Perugia, Italy
2 Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano, Turin, Italy
3 Department of Biopathology and Diagnostic Imaging, Policlinico Tor Vergata, Rome, Italy
4 Department of Cellular Biotechnologies and Hematology, Policlinico "La Sapienza", Rome, Italy
5 Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, USA
6 Department of Biochemistry and Medical Biotechnologies, University "Federico II", Neples, Italy
7 Laboratory of Hematopathology, University of Bologna, Policlinico S. Orsola, Bologna, Italy and
8 Munich Leukemia Laboratory GmbH, Munich, Germany

Correspondence: Brunangelo Falini, MD, Institute of Hematology, University of Perugia, Perugia, Italy. E-mail: faliniem{at}unipg.it

Acute myeloid leukemia carrying NPM1 mutations and cytoplasmic nucleophosmin (NPMc+ acute myeloid leukemia) represents one-third of adult AML (50–60% of all acute myeloid leukemia with normal karyotype) and shows distinct biological, pathological and clinical features. We confirm in 2562 patients with acute myeloid leukemia our previous observation that NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities. Taken together, these findings make NPMc+ acute myeloid leukemia a good candidate for inclusion in the upcoming World Health Organization classification.

Key words: acute myeloid leukemia, nucleophosmin, NPM, mutations, antibodies, immunohistochemistry.




This article has been cited by other articles:


Home page
 haematolHome page
C. Boonthimat, W. Thongnoppakhun, and C. U. Auewarakul
Nucleophosmin mutation in Southeast Asian acute myeloid leukemia: eight novel variants, FLT3 coexistence and prognostic impact of NPM1/FLT3 mutations
Haematologica, October 1, 2008; 93(10): 1565 - 1569.
[Abstract] [Full Text] [PDF]

Home page
 haematolHome page
A. Liso, F. Castiglione, A. Cappuccio, F. Stracci, R. F. Schlenk, S. Amadori, C. Thiede, S. Schnittger, P. J.M. Valk, K. Dohner, et al.
A one-mutation mathematical model can explain the age incidence of acute myeloid leukemia with mutated nucleophosmin (NPM1)
Haematologica, August 1, 2008; 93(8): 1219 - 1226.
[Abstract] [Full Text] [PDF]

Home page
 haematolHome page
B. Falini, M. P. Martelli, C. Mecucci, A. Liso, N. Bolli, B. Bigerna, A. Pucciarini, S. Pileri, G. Meloni, M. F. Martelli, et al.
Cytoplasmic mutated nucleophosmin is stable in primary leukemic cells and in a xenotransplant model of NPMc+ acute myeloid leukemia in SCID mice
Haematologica, May 1, 2008; 93(5): 775 - 779.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK TABLE OF CONTENTS ARCHIVE SUBSCRIPTIONS
Copyright © 2008 by the Ferrata Storti Foundation.