Published online 20 February 2008
Haematologica, Vol 93, Issue 3, 447-450 doi:10.3324/haematol.11934
Copyright © 2008 by Ferrata Storti Foundation
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Malignant Lymphomas

Autoimmune thrombocytopenia in non-Hodgkin’s lymphomas

Alexander W. Hauswirth1,, Cathrin Skrabs1, Christian Schützinger1, Markus Raderer2, Andreas Chott3, Peter Valent1, Klaus Lechner1, Ulrich Jäger1

1 Department of Medicine I, Division of Hematology and Hemostaseology and
2 Oncology
3 Department of Pathology, Medical University of Vienna, Vienna, Austria

Correspondence: Alexander Hauswirth, Department of Medicine I, Division of Haematology and Haemostaseology, Medical University of Vienna, Vienna, A 1090 Währingergürtel 18– 20, Austria. E-mail: alexander.hauswirth{at}meduniwien.ac.at

Autoimmune thrombocytopenia is a common immunehematologic complication in non-Hodgkin’s lymphomas and may complicate the treatment. We analyzed an original series from our institute as well as published cases of non-Hodgkin’s lymphomas (excluding chronic lymphocytic leukemia) associated with autoimmune thrombocytopenia with regard to demographic factors, prevalence in non-Hodgkin’s lymphoma subtypes and treatment outcome. The male/female ratio is 1.75. Half of the cases occurred prior to diagnosis of lymphoma. Chemotherapy is the best treatment in many non-Hodgkin’s lymphomas patients with autoimmune thrombocytopenia compared with standard treatment of autoimmune thrombocytopenia. Splenectomy is effective in splenic marginal zone lymphoma. Autoimmune thrombocytopenia in patients with non-Hodgkin’s lymphomas is potentially life-threatening and difficult to treat.

Key words: autoimmune thrombocytopenias, non-Hodgkin’s lymphoma.




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