Haematologica, Vol 93, Issue 3, 465-466 doi:10.3324/haematol.12183
Copyright © 2008 by Ferrata Storti Foundation
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Bone Marrow Failure

Cytokines in combination to treat radiation-induced myelosuppresssion: evaluation of SCF + glycosylated EPO + pegylated G-CSF as an emergency treatment in highly irradiated monkeys

Michel Drouet, Christophe Delaunay, Nancy Grenier, Philippe Garrigou, Jean-François Mayol, Francis Hérodin

Centre de Recherches du Service de Santé des Armées, La Tronche, France

Correspondence: Michel Drouet, Experimental Radiohematology Unit, Centre de Recherches du Service de Santé des Armées, 24 Avenue des Maquis du Grésivaudan, 38702 La Tronche, France. E-mail: micheldrouet{at}crssa.net

Multicytokine therapy may be useful to counteract radiation-induced myelosuppression. We assessed the stem cell factor + glycosylated erythropoietin + pegylated granulocyte colony-stimulating factor combination (SEG) as an emergency treatment. SEG in highly irradiated monkeys efficacy appeared to be restricted to granulopoiesis. Early administration of Erythropoietin did not prevent radiation-induced anemia.

Key words: hematopoiesis, cytokine, non human primate, irradiation.