Haematologica, Vol 93, Issue 3, 469-470 doi:10.3324/haematol.12029
Copyright © 2008 by Ferrata Storti Foundation
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Acute Myeloid Leukemia

Drug-induced hypersensitivity syndrome with rapid hematopoietic reconstitution during treatment for acute myeloid leukemia

Hiroshi I. Suzuki1, Takashi Asai1, Zenshiro Tamaki2, Akira Hangaishi1, Shigeru Chiba3, Mineo Kurokawa1,

1 Department of Hematology and Oncology
2 Department of Dermatology
3 Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan Key words: drug-induced hypersensitivity syndrome, immunorestitution disease, acute myeloid leukemia, chemotherapy, hematopoietic recovery

Correspondence: Mineo Kurokawa, MD, PhD. Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Phone: international +81.3.5800-9092. Fax: international +81.3.58408667. E-mail: kurokawa-tky{at}umin.ac.jp

Drug-induced hypersensitivity syndrome (DIHS) is a rare but severe life-threatening, drug-induced, systemic hypersensitivity reaction. We report two patients who developed DIHS during treatment for acute myeloid leukemia. Awareness of DIHS is necessary when systemic eruptions and high fever occur in leukemic patients, especially with rapid hematopoietic recovery after chemotherapies.